NDR1/2 kinases regulate membrane trafficking, enable efficient autophagy and prevent neurodegeneration
Flavia Roşianu, Simeon R. Mihaylov, Noreen Eder, Antonie Martiniuc, Suzanne Claxton, Helen R. Flynn, Shamsinar Jalal, Marie‐Charlotte Domart, Lucy Collinson, Mark J. Skehel, Ambrosius P. Snijders, Matthias Krause, Sharon A. Tooze, Sila K. Ultanir
This study shows that dual loss of NDR1/2 kinases in neurons causes neurodegeneration, disrupts endocytosis, and impairs autophagy by affecting membrane trafficking and protein homeostasis.
bioRxiv · Mar 28, 2022 · PreprintNeuroscience