Matthias Krause

The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling.

This study identifies Mena as a key mediator of Wnt signalosome endocytosis, showing it promotes Wnt signaling by binding LRP5/6 and facilitating receptor uptake.

Endophilin-Lamellipodin-VASP, key components in fast endophilin-mediated endocytosis, control actin polymerization within liquid-like condensates.

This study identifies Endophilin, Lamellipodin, and VASP as key components in fast endophilin-mediated endocytosis that regulate actin polymerization through liquid-like condensates.

NHSL3 interacts with Ena/VASP proteins and the Scar/WAVE complex and promotes cell migration.

This study identifies NHSL3 as a regulator of actin dynamics by interacting with Ena/VASP proteins and the Scar/WAVE complex, inhibiting Arp2/3 activity to promote cell migration.

The NHSL1-A complex interacts with the Arp2/3 complex and controls cell migration efficiency and chemotaxis.

This study identifies the NHSL1-A complex as a regulator of cell migration and chemotaxis by interacting with the Arp2/3 complex and modulating lamellipodia dynamics.

Nance-Horan Syndrome-like 1 interacts with endophilin A2 and Ena/VASP proteins to promote fast endophilin-mediated endocytosis.

This study identifies NHSL1's role in promoting fast endophilin-mediated endocytosis by interacting with EndoA2 and Ena/VASP proteins, enhancing actin polymerization at FEME sites.

GSK3 and Lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration

This study shows that GSK3 and Lamellipodin regulate lamellipodia formation and focal adhesion maturation in mouse neural crest migration.

Craniofacial dysmorphology in Down Syndrome is caused by increased dosage of Dyrk1a and at least three other genes

The paper identifies four Hsa21-orthologous genes, including Dyrk1a, that cause craniofacial dysmorphology in Down syndrome mouse models by reducing neural crest cell proliferation.

NDR1/2 kinases regulate membrane trafficking, enable efficient autophagy and prevent neurodegeneration

This study shows that dual loss of NDR1/2 kinases in neurons causes neurodegeneration, disrupts endocytosis, and impairs autophagy by affecting membrane trafficking and protein homeostasis.

GSK3 Controls Migration of the Neural Crest Lineage

This study identifies GSK3's role in regulating neural crest migration and shows its relevance in neuroblastoma cell migration.