Lucy Collinson

iSBEM automates ROI targeting in SBF-SEM using XRM maps, improving acquisition throughput while maintaining targeting precision in biological specimens.

This study develops a peptide-exchange system to efficiently study KIR binding to HLA-I molecules with peptide specificity.

This study uses targeted CRISPR screens to identify essential genes for Cryptosporidium survival, finding Cp23 is critical for gliding motility and reinfection.

This study identifies a Cryptosporidium virulence factor that modifies host intestinal microvilli by interacting with host proteins, similar to a bacterial virulence factor.

The paper introduces VP-CLEM-Kit, a cost-effective SR-vCLEM pipeline for visual proteomics, achieving 5-fold resolution improvement at 7-fold lower cost.

This study shows that Plasmodium falciparum undergoes a rapid metamorphosis after invading erythrocytes, mediated by PV6, which aids parasite survival by altering erythrocyte surface area.

The paper identifies a unique PI(4,5)P2-positive compartment formed during entosis and related engulfment processes, distinct from phagosomes and macropinosomes.

This paper introduces engineering solutions to enable non-destructive X-ray tomography of brain tissue at ultrastructural resolution, validated against electron microscopy.

The paper demonstrates the use of a femtosecond laser to prepare resin-embedded samples for correlative microscopy workflows, enabling precise targeting and trimming for high-resolution imaging techniques.

The paper tracks α-synuclein conformational changes in neurons and shows mitochondrial involvement in oligomerization and toxicity.

This study shows that dual loss of NDR1/2 kinases in neurons causes neurodegeneration, disrupts endocytosis, and impairs autophagy by affecting membrane trafficking and protein homeostasis.

The paper presents a method for automated 3D mitochondria segmentation in electron microscopy data, achieving high performance on rat and human cortex samples.

This study shows zebrafish enteric glia can proliferate and generate enteric neurons, similar to brain neural stem cells, and are regulated by Notch signaling.