Author

Suzanne Claxton

The Francis Crick InstituteORCID 0000-0002-7708-4682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Sila K. UltaniriD· 4 shared André T. LopesiD· 3 shared Simeon R. MihayloviD· 3 shared Helen R. FlynniD· 2 shared Lucas L. BaltusseniD· 2 shared Mark J. SkeheliD· 2 shared Aleksandar P. IvanoviD· 1 shared Almaz Huseynova· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersNeuroscience

Sila K. UltanirORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tracking gene expression of single mitochondria in live neurons using nanotweezers

Annie Sahota, Binoy Paulose Nadappuram, Siân C. Allerton, Flavie Lesept, Jack H. Howden, Suzanne Claxton, Yaxian Liu, Francesco A. Aprile, Josef T. Kittler, Michael J. Devine, Aleksandar P. Ivanov, Joshua B. Edel

The paper tracks mitochondrial gene expression in live neurons using nanotweezers and finds downregulation of MT-ND1 and MT-ATP6 after exposure to α-synuclein aggregates.

Journal of the American Chemical Society · Jun 9, 2026Peer-reviewedNeuroscience

CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex development

Simeon R. Mihaylov, André T. Lopes, Margaux Silvestre, Gaia Bianchini, Helen R. Flynn, Almaz Huseynova, Stephanie Strohbuecker, Llywelyn Griffith, Cristina Militti, Lucas L. Baltussen, Xiuming Yuan, Gabriel Morel, Suzanne Claxton, Kelvin Dempster, Flora C. Y. Lee, , Sila K. Ultanir

This study identifies CDKL5 as a kinase that phosphorylates nELAVL proteins, enhancing mRNA binding and protein synthesis, and shows its role in visual cortex development.

bioRxiv · May 29, 2026 · PreprintNeuroscience

CDKL5's role in microtubule-based transport and cognitive function

André T. Lopes, Ondine Janiv, Suzanne Claxton, Sila K. Ultanir

This study investigates how CDKL5 phosphorylation of MAP1S affects microtubule function and cognitive processes, showing impaired dynein motility and synaptic defects in mutant mice.

bioRxiv · Aug 28, 2024 · PreprintNeuroscience

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability

Marisol Sampedro Castañeda, Lucas L. Baltussen, André T. Lopes, Yichen Qiu, Liina Sirvio, Simeon R. Mihaylov, Suzanne Claxton, Jill C. Richardson, Gabriele Lignani, Sila K. Ultanir

This study identifies CDKL5 as a kinase that phosphorylates Cav2.3, altering its function and contributing to neuronal excitability in CDKL5 deficiency disorder.

Nature Communications · Dec 11, 2023Peer-reviewedNeuroscience

NDR1/2 kinases regulate membrane trafficking, enable efficient autophagy and prevent neurodegeneration

Flavia Roşianu, Simeon R. Mihaylov, Noreen Eder, Antonie Martiniuc, Suzanne Claxton, Helen R. Flynn, Shamsinar Jalal, Marie‐Charlotte Domart, Lucy Collinson, Mark J. Skehel, Ambrosius P. Snijders, Matthias Krause, Sharon A. Tooze, Sila K. Ultanir

This study shows that dual loss of NDR1/2 kinases in neurons causes neurodegeneration, disrupts endocytosis, and impairs autophagy by affecting membrane trafficking and protein homeostasis.

bioRxiv · Mar 28, 2022 · PreprintNeuroscience