The cancer-promoting enzyme PKM2 binds RNA via a positively charged regulatory patch
Pia Sommerkamp, Christian Schillinger, Karine Lapouge, Antonio Biancolella, Dunja Ferring–Appel, Matthias W. Hentze
This study shows PKM2 binds RNA through a positively charged surface patch, with RNA binding influenced by its oligomeric state and allosteric regulator FBP.
bioRxiv · Sep 23, 2026 · PreprintMolecular Biology