Matthias W. Hentze

The cancer-promoting enzyme PKM2 binds RNA via a positively charged regulatory patch

This study shows PKM2 binds RNA through a positively charged surface patch, with RNA binding influenced by its oligomeric state and allosteric regulator FBP.

Identification of RNA Targets of Classical and Non-Canonical RNA-binding Proteins by soniCLIP

This paper introduces soniCLIP, a CLIP-seq method that improves RNA target identification for RBPs by reducing input requirements and workflow complexity.

Liver sinusoidal endothelial cells integrate metabolic and immune signals for MAPK-dependent BMP6 regulation and hepcidin induction

This study shows that liver sinusoidal endothelial cells (LSECs) integrate metabolic and immune signals through the MAPK pathway to regulate BMP6 and induce hepcidin, maintaining iron homeostasis during inflammation and stress.

Muscle LIM Protein is a Non-Canonical RNA-Binding Protein that Engages in RNA-Dependent Cytoskeletal Assemblies

This study identifies MLP as a non-canonical RNA-binding protein in cardiomyocytes and shows its RNA-dependent interaction with cytoskeletal complexes.

Genomic G quadruplexes regulate mRNA splicing

The paper shows that genomic G quadruplexes regulate mRNA splicing by recruiting RNA-binding proteins, with implications for cardiac function.

RNA promotes mitochondrial import of F1-ATP synthase subunit alpha (ATP5A1)

The paper shows that specific cytosolic RNAs bind ATP5A1 precursor proteins and promote their mitochondrial import.

Improved discovery of RNA-binding protein binding sites in eCLIP data using DEWSeq

DEWSeq improves eCLIP data analysis by increasing the detection of RNA-binding protein binding sites and their functional elements.

The RNA-binding protein landscapes differ between mammalian organs and cultured cells

The paper characterizes RNA-binding protein landscapes in mouse organs using ex vivo eRIC, identifying over 1300 RBPs, many not previously found in cultured cells.

Small non-coding RNA Interactome Capture reveals pervasive, carbon source-dependent tRNA engagement of yeast glycolytic enzymes

The paper introduces snRIC2C, a method to identify small non-coding RNA-binding proteins, revealing that glycolytic enzymes like GAPDH bind tRNAs in a carbon source-dependent manner.

RNA regulates Glycolysis and Embryonic Stem Cell Differentiation via Enolase 1

The paper shows RNA regulates ENO1 enzyme activity, affecting glycolysis and stem cell differentiation in human and mouse cells.

Mechanism of riboregulation of p62 protein oligomerisation by vault RNA1-1 in selective autophagy

The paper identifies the molecular mechanism by which vault RNA1-1 regulates p62 oligomerisation, essential for selective autophagy.

The small non-coding vault RNA1-1 acts as a riboregulator of autophagy

This study identifies vault RNA1-1 as a riboregulator of autophagy by interacting with p62, showing that it modulates autophagic flux.

The Human RNA-Binding Proteome and Its Dynamics During Arsenite-Induced Translational Arrest

The paper introduces XRNAX, a method to purify protein-RNA complexes, and shows it captures all RNA biotypes and reveals dynamic changes in the RNA-bound proteome during arsenite-induced stress.