Karine Lapouge

This study benchmarks DSF across labs, showing variability in thermal stability parameters due to instruments, workflows, and fluorescence readouts, with harmonization and centralized analysis improving consistency.

This study identifies the CD2 intracellular domain of PCDH15 as an intrinsically disordered polymer with biophysical properties relevant to auditory mechanotransduction.

This study shows PKM2 binds RNA through a positively charged surface patch, with RNA binding influenced by its oligomeric state and allosteric regulator FBP.

The paper quantifies co-accessibility between cis-regulatory elements in Drosophila using single-molecule footprinting and long-read sequencing, revealing coordinated regulation across genomic distances.

The paper identifies short linear motifs in Toxoplasma gondii secreted proteins using a computational pipeline and validates some predictions experimentally.

The paper determines cryo-EM structures of MEK1 activating ERK2, elucidating specificity and activation mechanisms in the MAPK pathway.

This study shows that selective class IIa HDAC inhibition improves diastolic dysfunction in HFpEF without adverse effects.

AlphaDesign uses AlphaFold to design novel protein structures, including monomers, dimers, and higher-order complexes, showing structural integrity and conformational switching capabilities.

This paper identifies the RNA binding specificity of Hrp48, showing it binds the msl-2 mRNA 3' UTR independently of Sxl and Unr downstream of their binding sites.

This study shows that Trim66 deficiency in male mice leads to paternal transmission of intrauterine overgrowth in offspring.

This study reveals how the dsRBD2 domain of the DExH-type helicase maleless orchestrates RNA unwinding through structural transitions, independent of ATP.

The paper characterizes the quaternary hunchback mRNA repression complex formed by Brat, Pum, and Nanos, revealing its flexibility and independent binding of RNA components.