Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart
Jessica Gambardella, Antonella Fiordelisi, Federica Andrea Cerasuolo, Antonietta Buonaiuto, Roberta Avvisato, Alessandro Viti, Eduardo Sommella, Pietro Campiglia, Valeria D’Argenio, Nella Prevete, Antonio Pezone, Stefania D’Apice, Giovanna Giuseppina Altobelli, Fahimeh Varzideh, Shivangi Pande, , Guido Iaccarino
This study identifies mitochondrial dysfunction and impaired mitophagy as key drivers of cardiac damage in Fabry disease and shows that L-arginine supplementation can prevent cardiac abnormalities.
Cell Reports · Oct 26, 2026Peer-reviewedPathology