Pietro Campiglia

Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart

This study identifies mitochondrial dysfunction and impaired mitophagy as key drivers of cardiac damage in Fabry disease and shows that L-arginine supplementation can prevent cardiac abnormalities.

Ion Mobility-Guided Tandem Mass Spectrometry Imaging Resolves Bis(monoacylglycero)phosphate and Phosphatidylglycerol Isomers in Tissue

This paper develops an ion mobility-guided MSI workflow to distinguish BMP and PG isomers in tissue, showing reduced cross-talk and enabling structural assignment in mouse brain and a CLN3-knockout model.

Structural studies of mycobacterial HptG reveal a silent state and offer insights into TLR4 activation

This study presents the first crystal structure of HtpGMtb, revealing a conformationally silent dimer and direct TLR4 interaction, providing insights into its catalytic activity and TLR4 activation mechanism.

A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis.

This study shows that a Muc2 mutation in Winnie mice leads to colitis-associated tumorigenesis driven by the gut microbiome and metabolome, with SPF conditions promoting severe disease and CAC.

A high-throughput 3D culture microfluidic platform for multi-parameter phenotypic and omics profiling of patient-derived organoids

This paper introduces a high-throughput microfluidic platform for organoid culture and multi-omics profiling, demonstrating its utility in clinical and drug discovery settings.