Eduardo Sommella

Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart

This study identifies mitochondrial dysfunction and impaired mitophagy as key drivers of cardiac damage in Fabry disease and shows that L-arginine supplementation can prevent cardiac abnormalities.

Lysosomal proteome and lipidome analyses of intestinal cells reveal the crucial role of bis(monoacylglycero)phosphate for autophagosome-lysosome fusion

This study identifies BMP's role in autophagosome-lysosome fusion by analyzing lysosomal proteomes and lipidomes in GNPTAB-deficient intestinal cells.

Ion Mobility-Guided Tandem Mass Spectrometry Imaging Resolves Bis(monoacylglycero)phosphate and Phosphatidylglycerol Isomers in Tissue

This paper develops an ion mobility-guided MSI workflow to distinguish BMP and PG isomers in tissue, showing reduced cross-talk and enabling structural assignment in mouse brain and a CLN3-knockout model.

A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis.

This study shows that a Muc2 mutation in Winnie mice leads to colitis-associated tumorigenesis driven by the gut microbiome and metabolome, with SPF conditions promoting severe disease and CAC.

A high-throughput 3D culture microfluidic platform for multi-parameter phenotypic and omics profiling of patient-derived organoids

This paper introduces a high-throughput microfluidic platform for organoid culture and multi-omics profiling, demonstrating its utility in clinical and drug discovery settings.