Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH
Tobias Obermann, Teri Sakshaug, Vishnu Vignesh Kanagaraj, Andreas Abentung, Mirta Mittelstedt Leal de Sousa, Lars Hagen, Antonio Sarno, Magnar Bjørås, Katja Scheffler
The paper investigates the role of 8-oxoguanine (OG) in gene transcription, showing that OG accumulation in promoter regions correlates with metabolic and damage response gene expression, independent of repair by OGG1 and MUTYH.
Redox Biology · Dec 5, 2024Peer-reviewedGenomics