Katja Scheffler

This study shows Ogg1 has opposing effects on glial states in Alzheimer's disease, improving memory and reducing amyloid burden in a mouse model while impairing memory under physiological conditions.

Bivariate GSA-MiXeR is a tool that models genetic correlations between two traits to identify genomic regions associated with psychiatric and neurodegenerative disorders using single-cell RNA sequencing data.

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

This study performs APOE-stratified GWAS to uncover genetic mechanisms underlying Alzheimer's disease risk and response to therapies.

The paper investigates the role of 8-oxoguanine (OG) in gene transcription, showing that OG accumulation in promoter regions correlates with metabolic and damage response gene expression, independent of repair by OGG1 and MUTYH.

This study shows that DNA glycosylases Ogg1 and Mutyh regulate gene expression of PRC2 target genes, affecting memory formation through epigenetic remodeling in the brain.

This study investigates the role of Neil3 in Alzheimer's disease progression, finding age- and sex-dependent effects on amyloid pathology and memory in a mouse model.

This study shows that NEIL1 and NEIL2 DNA glycosylases work together to regulate anxiety and learning in mice, despite not affecting oxidative DNA damage levels.