Magnar Bjørås

This study shows Ogg1 has opposing effects on glial states in Alzheimer's disease, improving memory and reducing amyloid burden in a mouse model while impairing memory under physiological conditions.

This study identifies novel genes involved in ciprofloxacin-induced DNA supercompaction in E. coli using high-content imaging and machine learning.

This paper identifies a direct interaction between the RecBCD complex and the DNA sliding clamp in E. coli, showing its role in DNA repair and survival after DNA damage.

This study uses two-photon imaging to show that mitophagy decreases with age in mouse somatosensory cortex neurons and astrocytes, with astrocytes showing higher mitophagy levels than neurons, and NAD+ treatment improves mitophagy in aged mice.

This study shows lactate treatment improves cognitive function and molecular biomarkers in Alzheimer's mice and wild-type controls.

The paper shows that transient SUMOylation inhibition in human pre-adipocytes leads to stable beige differentiation when combined with PPARG activation.

This study investigates APE1's role in repairing damaged telomeric i-motif structures and its interaction with PCBP1 in maintaining telomere integrity.

The paper maps H2A.Z incorporation during mouse oogenesis, identifying distinct patterns and their relationship with epigenetic marks and transposable elements.

This paper introduces two single-cell sequencing methods for detecting 5mC and 5hmC, showing increased 5hmC in aging mouse hippocampus.

This study shows that ciprofloxacin induces DNA supercompaction in E. coli, requiring RecN and dependent on RecA, as part of a DNA damage response.

This study shows JAK inhibitors like baricitinib suppress IFN-stimulated genes, aiding viral propagation by reducing antiviral defenses.

This study shows that inhibiting SUMOylation with TAK-981 in mice reduces adipose tissue weight and adipocyte size, mimicking genetic hypoSUMOylation effects.

The paper investigates the role of 8-oxoguanine (OG) in gene transcription, showing that OG accumulation in promoter regions correlates with metabolic and damage response gene expression, independent of repair by OGG1 and MUTYH.

This study shows that DNA glycosylases Ogg1 and Mutyh regulate gene expression of PRC2 target genes, affecting memory formation through epigenetic remodeling in the brain.

This study shows that loss of Aag in mice reduces DNA damage and alters gene expression in the brain, leading to reduced anxiety and improved memory.

The paper shows that mitotic chromosome condensation resets transcriptional homeostasis by preventing unscheduled gene expression and transcriptional drift in the subsequent interphase.

This study investigates SARS-CoV-2-induced host responses in human lung epithelial cells using multi-omics approaches, revealing altered signaling pathways and metabolic changes.

This study investigates the role of Neil3 in Alzheimer's disease progression, finding age- and sex-dependent effects on amyloid pathology and memory in a mouse model.

This study shows that HCAR1 promotes tissue regeneration after neonatal hypoxia-ischemia by regulating neural progenitor cell proliferation and microglia activation.

This study shows NEIL3 affects spatial stability in hippocampal neurons by altering transcription of NMDA receptor subunits and immediate early genes.

This study shows that NEIL1 and NEIL2 DNA glycosylases work together to regulate anxiety and learning in mice, despite not affecting oxidative DNA damage levels.

The paper shows AAG associates with transcription elongation to coordinate DNA repair with gene expression, revealing roles of aberrantly methylated bases in gene regulation.

This study identifies critical host-virus interaction nodes through network analysis and drug re-purposing, revealing key targets for antiviral therapies.

This study shows that m6dA accumulation in DNA of prefrontal cortical neurons is linked to fear extinction learning and gene expression.