Filopodia-mediated trans-endocytosis
Hanna Grobe, Marcela Xiomara Rivera Pineda, Sujan Ghimire, Marie-Catherine Laisne, Anna Serafia Nylund, Monika Vaitkevičiūtė, Helena Vihinen, Anu Prakash, Johanna Tammi, Marjaana Ojalill, Pia Boström, Pauliina Hartiala, Johanna I. Englund, Emilia Peuhu, Eija Jokitalo, Guillaume Jacquemet
The paper shows filopodia can penetrate neighboring cells to form impact sites that initiate trans-endocytosis, with internalized tips often being double-membraned and associated with endoplasmic reticulum.
bioRxiv · Feb 11, 2026 · PreprintCell Biology