Sujan Ghimire

This study identifies two distinct mechanisms by which pancreatic cancer cells extravasate: protrusion-driven invasion and endothelial retraction, with implications for anti-metastatic strategies.

The paper shows filopodia can penetrate neighboring cells to form impact sites that initiate trans-endocytosis, with internalized tips often being double-membraned and associated with endoplasmic reticulum.

This study uses fast label-free live imaging and deep learning to analyze cancer cell arrest on endothelial monolayers, finding CD44-HA interactions and flow dynamics are key factors.

This paper identifies S166 phosphorylation on LSD1 as a regulatory switch that controls gene activation, chromatin remodeling, and tumor microenvironment in non-hormonal cancer cells.

Fast4DReg corrects drift in 3D microscopy datasets using 2D cross-correlations, outperforming existing tools in speed and accuracy.