Helena Vihinen

Filopodia-mediated trans-endocytosis

The paper shows filopodia can penetrate neighboring cells to form impact sites that initiate trans-endocytosis, with internalized tips often being double-membraned and associated with endoplasmic reticulum.

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol

This study shows that Sac1 regulates Golgi V-ATPase assembly by controlling TGN membrane composition through lipid exchange, leading to Golgi fragmentation and impaired glycosylation.

Ribosome-binding protein 1, RRBP1, maintains peroxisomal biogenesis

This study identifies RRBP1 as a novel peroxisome biogenesis factor in human cells, showing it promotes peroxisome formation and stabilizes peroxisomal proteins.

Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes

This study shows mitochondrial dysfunction in astrocytes disrupts primary ciliary homeostasis, linking mitochondrial stress to ciliary signaling and neurodegenerative disease mechanisms.

Functional, metabolic and transcriptional maturation of stem cell derived beta cells

This study generates and benchmarks functionally mature stem cell-derived islets, showing they closely resemble primary adult islets in transcriptional and functional properties.