Eija Jokitalo

Filopodia-mediated trans-endocytosis

The paper shows filopodia can penetrate neighboring cells to form impact sites that initiate trans-endocytosis, with internalized tips often being double-membraned and associated with endoplasmic reticulum.

Multimodal approach to characterize surgically removed epileptogenic zone from patients with focal drug-resistant epilepsy: from operating room to wet lab

The paper develops a protocol to characterize epileptogenic tissue using multimodal data from surgical samples, aiming to improve diagnosis and treatment of drug-resistant epilepsy.

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol

This study shows that Sac1 regulates Golgi V-ATPase assembly by controlling TGN membrane composition through lipid exchange, leading to Golgi fragmentation and impaired glycosylation.

Dispersal behavior rather than dispersal morphology creates social polymorphism in Formica ants

This study shows that dispersal behavior, not morphology, drives social polymorphism in Formica ants, suggesting a 'behavior first' evolutionary mechanism.

Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes

This study shows mitochondrial dysfunction in astrocytes disrupts primary ciliary homeostasis, linking mitochondrial stress to ciliary signaling and neurodegenerative disease mechanisms.

Functional, metabolic and transcriptional maturation of stem cell derived beta cells

This study generates and benchmarks functionally mature stem cell-derived islets, showing they closely resemble primary adult islets in transcriptional and functional properties.

DeepACSON: Automated Segmentation of White Matter in 3D Electron Microscopy

DeepACSON segments myelinated axons, cell nuclei, and mitochondria in low-resolution 3D-EM datasets of rat brain tissue, capturing morphological changes post-injury.

Automated 3D Axonal Morphometry of White Matter

The paper develops an automated 3D segmentation pipeline for axonal morphology analysis in rat white matter and finds reduced axonal diameter in chronic brain injury.