It takes two (Ku) to repair: Mechanistic insights into the minimal NHEJ system of Mycobacterium Tuberculosis
Florian Morati, Evgeniya Pavlova, Anusha Budida, Selma Fornander, Elin Persson, Jagadeesh Sundaramoorthy, Raphaël Guérois, Fredrik Westerlund
This study investigates the minimal NHEJ system in M. tuberculosis using structural simulations, assays, and single-molecule analysis, revealing Ku-LigD interactions and their impact on enzymatic activity.
bioRxiv · Dec 17, 2025 · PreprintBiochemistry