Fredrik Westerlund

A Platinum Butterfly Effect: Small Changes Turn an Anticancer Drug into a Non-toxic Metalloantibiotic with In Vivo Efficacy

This paper describes the development of a platinum-based antibiotic, Pt1, which shows potent antibacterial activity against resistant Staphylococcus aureus strains and demonstrates in vivo efficacy in a murine infection model.

SIZE DETERMINATION AND MULTIPLEXED FLUORESCENCE-BASED PHENOTYPING OF SINGLE CELL-DERIVED MEMBRANE VESICLES USING A NANOFLUIDIC DEVICE

The paper introduces Nano-SMF, a nanofluidic method for size and 3-color fluorescence phenotyping of single nanoparticles, demonstrating improved accuracy over existing techniques for EV analysis.

MYC modulates TOP2A diffusion to promote substrate detection and activity

This study shows MYC enhances TOP2A diffusion, promoting its substrate binding and chromatin engagement, thereby stimulating topoisomerase activity.

It takes two (Ku) to repair: Mechanistic insights into the minimal NHEJ system of Mycobacterium Tuberculosis

This study investigates the minimal NHEJ system in M. tuberculosis using structural simulations, assays, and single-molecule analysis, revealing Ku-LigD interactions and their impact on enzymatic activity.