Pannexin-1 regulates cellular identity and excitability in the developing cortex
Norma K. Hylton, David J Kang, Steven C. Decker, David Exposito-Alonso, Christie N Cambridge, Sean R Golinski, Karla Soriano, Madeline C. Burke, Ximena Gómez-Maqueo, Qiurui Chen, Ruilong Hu, Jennifer N. Partlow, Maya Talukdar, Rebecca Andersen, Trenton M Buckner, , Richard S. Smith
This study identifies de novo PANX1 mutations in individuals with PMG and microcephaly, showing they disrupt glycosylation, increase ATP release, and alter cortical development through ion conductance and cell fate regulation.
bioRxiv · Aug 26, 2026 · PreprintNeuroscience