Author

Ellen M. DeGennaro

Boston Children's HospitalORCID 0000-0001-5506-6451Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Anusha Doddi· 1 shared Bernd Zetsche· 1 shared Christie N CambridgeiD· 1 shared Christopher A. WalshiD· 1 shared Chunhui CaiiD· 1 shared David A. ScottiD· 1 shared David Exposito-AlonsoiD· 1 shared David J Kang· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Anusha Doddi

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 26, 2026

Pannexin-1 regulates cellular identity and excitability in the developing cortex

Norma K. Hylton, David J Kang, Steven C. Decker…·Richard S. Smith

This study identifies de novo PANX1 mutations in individuals with PMG and microcephaly, showing they disrupt glycosylation, increase ATP release, and alter cortical development through ion conductance and cell fate regulation.

1 citation

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyNature BiotechnologyPeer-reviewedFeb 1, 2017

Multiplex gene editing by CRISPR-Cpf1 through autonomous processing of a single crRNA array

Bernd Zetsche, Matthias Heidenreich, Prarthana Mohanraju…·Feng Zhang

The paper demonstrates multiplex gene editing in mammalian cells and mouse brains using a single CRISPR array processed by Cpf1 without requiring additional factors.

28 citations

mousehuman

𝕏 PostBluesky