Chunhui Cai

This study identifies de novo PANX1 mutations in individuals with PMG and microcephaly, showing they disrupt glycosylation, increase ATP release, and alter cortical development through ion conductance and cell fate regulation.

This study uses single-cell spatial transcriptomics on cryopreserved human lung slices to identify molecular features of pulmonary fibrosis niches and their associated signaling pathways.

The paper uses spatial single-cell analysis to uncover molecular and structural development of human fetal cortex, revealing early layer and area specification.