JNK knockdown enhances CAR-T cell cytotoxicity
Charles J. Kuhlmann, Chloe E Jepson, Madison T Blucas, Fatema M Suleiman, Anusha Manda, Yoshiko N Kamata, Masakazu Kamata
This study shows that knocking down JNK in CAR-T cells increases their cytotoxicity against ovarian cancer by enhancing granzyme B expression through NFATc1.
bioRxiv · Aug 14, 2025 · PreprintImmunology