The KDM6 histone demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells
Adam P. Cribbs, Edward S. Hookway, Clarence Yapp, KaHing Che, James E. Dunford, Karina Gutheridge, Charlotte Palmer, Federica Lari, Graham Wells, Martin Philpott, Peter Cain, Deborah H. Brotherton, Eleanor Calcutt, Anvesha Saxena, Hal Drakesmith, , Udo C. T. Oppermann
This study shows GSK-J4, a KDM6 inhibitor, induces metal and stress responses in multiple myeloma cells by increasing intracellular Zn2+ and activating metallothionein gene expression.
RSC Chemical Biology · Jan 1, 2026Peer-reviewedCell Biology