Udo C. T. Oppermann

The paper develops a spatial tri-omics workflow to map genetically distinct myeloma subclones in bone marrow, showing they occupy spatially and biologically distinct niches.

This study identifies BRD9 inhibition as a strategy to enhance radiosensitivity in glioblastoma by modulating the MYC pathway, without significant cytotoxicity under normal conditions.

This study identifies CBP/p300 inhibition as a strategy to overcome vincristine resistance in medulloblastoma by targeting genes involved in drug resistance.

This study compares nanopore direct RNA and PCR-cDNA sequencing protocols, showing distinct 5' and 3' coverage biases affecting transcript-level analysis but similar gene-level accuracy.

The paper identifies a therapy-driven genomic double-hit (1pCEN LOH and 1q gain) in relapsed/refractory myeloma, associated with poor prognosis and clonal expansion.

The paper identifies early plasma proteomic changes preceding amyloidosis diagnosis, showing cardiac and immune dysregulation before clinical symptoms.

The paper identifies HDAC6 as an epigenetic vulnerability in TMZ-resistant glioblastoma models and shows HDAC6 inhibitors can restore TMZ sensitivity.

This study shows GSK-J4, a KDM6 inhibitor, induces metal and stress responses in multiple myeloma cells by increasing intracellular Zn2+ and activating metallothionein gene expression.

This paper introduces FIRESCAPE, a radiolabeling method to study extracellular histone H3 clearance and effects, revealing distinct behaviors compared to intact nucleosomes.

The paper integrates multi-omics data from uterine fibroids, myometrium, and endometrium to identify differential splicing and molecular pathways associated with abnormal uterine bleeding.

The paper identifies BRPF1 as a key regulator of Taxol resistance in TNBC through genetic and chemical screens, showing its inhibition sensitizes resistant cells to chemotherapy.

This study identifies altered plasma lipid profiles in rodent PCOS models using targeted mass spectrometry, revealing both similarities and differences compared to human PCOS.

This study identifies ATF4-mediated metabolic stress response as a therapeutic target in chordoma, showing that EPRS inhibitors reduce cell viability and inhibit tumor growth in vivo.

This paper introduces comBOs, a new human bone and lympho-myeloid bone marrow organoid model that includes multiple cell types and improves upon existing models for studying haematopoietic disorders.

The paper introduces an anchor-enhanced bead design to reduce oligonucleotide synthesis errors in single-cell sequencing, improving UMI recovery and feature detection.

The paper uses mass cytometry to analyze stemness states in PDAC, revealing molecular heterogeneity and identifying a subset with plastic phenotypes.

The paper demonstrates that PCR errors significantly affect UMI-based absolute counting in sequencing data and proposes a solution using homotrimeric nucleotide blocks to correct these errors.

This study identifies AF10 as a barrier to somatic cell reprogramming by regulating H3K79 methylation, showing that its suppression enhances reprogramming efficiency.

This paper introduces scBUC-seq, a method to correct barcode and UMI errors in single-cell sequencing, enabling direct Nanopore transcriptome sequencing with improved accuracy.

This study shows that BRD9 and ncBAF complexes maintain somatic cell identity and hinder reprogramming, with BRD9 inhibition increasing iPSC generation efficiency.