Eleanor Calcutt

The paper develops a spatial tri-omics workflow to map genetically distinct myeloma subclones in bone marrow, showing they occupy spatially and biologically distinct niches.

This study compares nanopore direct RNA and PCR-cDNA sequencing protocols, showing distinct 5' and 3' coverage biases affecting transcript-level analysis but similar gene-level accuracy.

This study shows GSK-J4, a KDM6 inhibitor, induces metal and stress responses in multiple myeloma cells by increasing intracellular Zn2+ and activating metallothionein gene expression.

This study identifies ATF4-mediated metabolic stress response as a therapeutic target in chordoma, showing that EPRS inhibitors reduce cell viability and inhibit tumor growth in vivo.

The paper introduces an anchor-enhanced bead design to reduce oligonucleotide synthesis errors in single-cell sequencing, improving UMI recovery and feature detection.