Martin Philpott

The paper identifies HDAC6 as an epigenetic vulnerability in TMZ-resistant glioblastoma models and shows HDAC6 inhibitors can restore TMZ sensitivity.

This study shows GSK-J4, a KDM6 inhibitor, induces metal and stress responses in multiple myeloma cells by increasing intracellular Zn2+ and activating metallothionein gene expression.

This paper introduces FIRESCAPE, a radiolabeling method to study extracellular histone H3 clearance and effects, revealing distinct behaviors compared to intact nucleosomes.

The paper integrates multi-omics data from uterine fibroids, myometrium, and endometrium to identify differential splicing and molecular pathways associated with abnormal uterine bleeding.

The paper identifies BRPF1 as a key regulator of Taxol resistance in TNBC through genetic and chemical screens, showing its inhibition sensitizes resistant cells to chemotherapy.

This study identifies RBBP4 as a critical regulator of cell cycle progression in TMZ-resistant glioblastoma through CRISPR screens and functional analyses.

This study identifies altered plasma lipid profiles in rodent PCOS models using targeted mass spectrometry, revealing both similarities and differences compared to human PCOS.

The paper introduces an anchor-enhanced bead design to reduce oligonucleotide synthesis errors in single-cell sequencing, improving UMI recovery and feature detection.

The paper demonstrates that PCR errors significantly affect UMI-based absolute counting in sequencing data and proposes a solution using homotrimeric nucleotide blocks to correct these errors.

This study identifies AF10 as a barrier to somatic cell reprogramming by regulating H3K79 methylation, showing that its suppression enhances reprogramming efficiency.

This paper introduces scBUC-seq, a method to correct barcode and UMI errors in single-cell sequencing, enabling direct Nanopore transcriptome sequencing with improved accuracy.

This study shows that BRD9 and ncBAF complexes maintain somatic cell identity and hinder reprogramming, with BRD9 inhibition increasing iPSC generation efficiency.