Iron Deficiency Drives Sarcopenia in the Elderly: HIF-1α-Mediated Fibro-Adipogenic Progenitor Differentiation Induces Fat Infiltration and Impairs Muscle Function
Quanzhong Ren, G. Yang, Dingding Wang, Wenkai Wu, Yi Wang, Jiahua Feng, Kairui Ma, Anyi Guo, Mingxing Fan, Yuqing Sun, Zhao Lang, Xieyuan Jiang, Yajun Liu, L Wang, Renxian Wang
This study shows that iron deficiency stabilizes HIF-1, promoting fat infiltration in muscle by altering fibro-adipogenic progenitor differentiation and impairing muscle repair.
bioRxiv · Jan 19, 2026 · PreprintCell Biology