Integration of iPSC-derived microglia into human midbrain organoids enhances microglial maturation and inflammatory signaling
Emma J. MacDougall, Ghislaine Deyab, Apoline Ormancey, Jialun Li, Taylor Goldsmith, Paula Lépine, Maria Baeza Trallero, Nadja Finkel, Julien Sirois, Martin H. Berryer, Thomas M. Durcan, Edward A. Fon
This study integrates iPSC-derived microglia into human midbrain organoids to enhance microglial maturation and inflammatory signaling, revealing altered transcriptional signatures in dopaminergic neurons and astrocytes.
bioRxiv · Apr 7, 2026 · PreprintNeuroscience