Author
Montreal Neurological Institute and Hospital
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
James P. W. Reeves, Sabra Rostami, Mostafa Rammal, Andrei Bocan, Paula Lépine, Matthew J. Harrington, Thomas M. Durcan, Christopher Moraes
This study shows that tunable yield stress in biomaterials affects organoid morphogenesis, with optimal yield stress promoting specific developmental features.
Small · Jul 11, 2026Peer-reviewedBiophysics
Maria Baeza Trallero, Ella Villeneuve, Paula Lépine, Andrea I. Krahn, Carol X.‐Q. Chen, Wolfgang Reintsch, María José Castellanos‐Montiel, Thomas M. Durcan, Martin H. Berryer
This study uses adeno-associated virus to image and analyze 3D morphology and connectivity of neurons and astrocytes in living human midbrain organoids over time.
bioRxiv · May 16, 2026 · PreprintNeuroscience
Emma J. MacDougall, Ghislaine Deyab, Apoline Ormancey, Jialun Li, Taylor Goldsmith, Paula Lépine, Maria Baeza Trallero, Nadja Finkel, Julien Sirois, Martin H. Berryer, Thomas M. Durcan, Edward A. Fon
This study integrates iPSC-derived microglia into human midbrain organoids to enhance microglial maturation and inflammatory signaling, revealing altered transcriptional signatures in dopaminergic neurons and astrocytes.
bioRxiv · Apr 7, 2026 · PreprintNeuroscience
Rhalena A. Thomas, Julien Sirois, Shu‐Ming Li, Alexandre Gestin, Ghislaine Deyab, Valerio E. C. Piscopo, Paula Lépine, Meghna Mathur, Carol X.‐Q. Chen, Vincent Soubannier, Taylor Goldsmith, Lama M. Fawaz, Thomas M. Durcan, Edward A. Fon
The paper develops a flow cytometry pipeline called CelltypeR to annotate and characterize cell types in brain organoids, identifying dopamine neuron subtypes and tracking cell type dynamics over time.
bioRxiv · Nov 11, 2022 · PreprintNeuroscience
Nguyen‐Vi Mohamed, Julien Sirois, Janani Ramamurthy, Meghna Mathur, Paula Lépine, Éric Deneault, Gilles Maussion, Michaël Nicouleau, Carol X.‐Q. Chen, Narges Abdian, Vincent Soubannier, Eddie Cai, Harris Nami, Rhalena A. Thomas, Dingke Wen, , Thomas M. Durcan
This study uses midbrain organoids from SNCA triplication patients to model synucleinopathy features, showing increased alpha-synuclein expression and aggregation linked to dopaminergic neuron loss.
Brain Communications · Sep 23, 2021Peer-reviewedNeuroscience
Nguyen‐Vi Mohamed, Paula Lépine, María Lacalle‐Aurioles, Julien Sirois, Meghna Mathur, Wolfgang Reintsch, Lenore K. Beitel, Edward A. Fon, Thomas M. Durcan
This study develops microfabricated disks to scale up midbrain organoid generation, reducing labor and variability while maintaining viability for Parkinson's disease research.
Methods · Jul 24, 2021Peer-reviewedNeuroscience
Katsuhisa Masaki, Yoshifumi Sonobe, Ghanashyam D. Ghadge, Peter Pytel, Paula Lépine, Florian Pernin, Qiao‐Ling Cui, Jack Perry Antel, Stéphanie Zandee, Alexandre Prat, Raymond P. Roos
The paper investigates altered expression and mislocalization of RNA-binding proteins TDP-43 and PTB in multiple sclerosis lesions and cultured oligodendrocytes, linking them to demyelination and neurodegeneration.
bioRxiv · Nov 5, 2019 · PreprintNeuroscience