Jialun Li

This study integrates iPSC-derived microglia into human midbrain organoids to enhance microglial maturation and inflammatory signaling, revealing altered transcriptional signatures in dopaminergic neurons and astrocytes.

This study shows that midbrain organoids with SNCA gene triplication exhibit PD-like neural activity changes, which can be reversed by dopamine agonists.

The paper uses machine learning on single-nuclei RNA sequencing data to identify GPC6 as a genetic risk factor for Parkinson's disease.

PhysiPKPD integrates pharmacokinetics and pharmacodynamics into PhysiCell models to enhance in silico simulations of molecular therapies.