Ghislaine Deyab

This study integrates iPSC-derived microglia into human midbrain organoids to enhance microglial maturation and inflammatory signaling, revealing altered transcriptional signatures in dopaminergic neurons and astrocytes.

This study shows that midbrain organoids with SNCA gene triplication exhibit PD-like neural activity changes, which can be reversed by dopamine agonists.

This study investigates the role of cathepsin B in Parkinson's disease by analyzing genetic variants and manipulating catB function in cell models to assess its impact on lysosomal activity and alpha-synuclein clearance.

The paper develops a flow cytometry pipeline called CelltypeR to annotate and characterize cell types in brain organoids, identifying dopamine neuron subtypes and tracking cell type dynamics over time.