IDRs lead the way: Cooperativity between intrinsically disordered regions and structured interaction domains drives enrichment in transcription condensates
Arad Abazari, Dinitha Yasas Caldera, Alisha Budhathoki, Ganesh Pandey, Mehdi Shafiei Aporvari, Filmon Alem Medhanie, Jan-Hendrik Spille
The paper shows that intrinsically disordered regions (IDRs) alone are insufficient to explain the enrichment of full-length transcription proteins in condensates, suggesting a need for structured domains in binding interactions.
Frontiers in Biophysics · Aug 19, 2026Peer-reviewedCell Biology