Ganesh Pandey

IDRs lead the way: Cooperativity between intrinsically disordered regions and structured interaction domains drives enrichment in transcription condensates

The paper shows that intrinsically disordered regions (IDRs) alone are insufficient to explain the enrichment of full-length transcription proteins in condensates, suggesting a need for structured domains in binding interactions.

Extracting anomalous diffusion parameters from multi-state ensembles of short single molecule trajectories.

The paper evaluates analysis methods for extracting diffusion parameters from single-molecule trajectories and shows that single-track analysis outperforms bulk methods.

Transcription condensates are promoter hubs that enhance transcriptional bursts

This study uses super-resolution microscopy to show that Pol II clusters form promoter hubs with layered chromatin organization, enhancing transcriptional bursts through cohesin loop extrusion.