ER oxidoreductin-1α and unfolded protein response as sex-dependent drivers of cardiorenal dysfunction in experimental autoimmune encephalomyelitis
Kayla L. Nguyen, Kelly Tammen, A.M. McDermott, Sreejita Arnab, Ari Hoffman, Maeva Talla, Nikhil Agarwal, Erin C. Jones, Aravind Meyyappan, David Mendelowitz, Yair Argon, John R. Bethea
This study investigates sex-specific cardiorenal dysfunction in EAE, finding distinct ER stress/UPR alterations and sex-dependent therapeutic responses to ERO1 inhibition and IRE1 activation.
bioRxiv · Oct 6, 2025 · PreprintMolecular Biology