John R. Bethea

This study shows that TNFR2 agonism can prevent and reverse OA-induced cardiac dysfunction in female mice and delay systolic decline in males, revealing sex-specific cardiac effects of OA.

This study shows oxytocin improves survival and respiratory function in rats with opioid-induced respiratory depression caused by fentanyl or fentanyl-xylazine combinations, outperforming naloxone in some cases.

This study shows that TNFR2 signaling in hippocampal Nex/Neurod6 neurons is critical for chronic neuropathic pain recovery, acting through sex-dependent opioid and endocannabinoid pathways.

This study characterizes a novel mouse model of OA-induced heart failure, revealing sex-specific cardiac remodeling and molecular pathways associated with different HF phenotypes.

This study investigates sex-specific cardiorenal dysfunction in EAE, finding distinct ER stress/UPR alterations and sex-dependent therapeutic responses to ERO1 inhibition and IRE1 activation.

This study identifies OXT receptor expression in brainstem cardiac vagal neurons and shows that OXT selectively activates DMNX CVNs to induce bradycardia.

This study shows that increased IRE1 activity in a mouse model of EAE reduces inflammation and improves motor function, suggesting context-dependent protective effects of ER stress.

This study investigates TNFR1/p38αMAPK signaling in Nex+ supraspinal neurons and its role in sex-specific chronic neuropathic pain, finding that it is male-specific and that estrogen receptor β interference affects therapeutic efficacy in females.