David Mendelowitz

This study shows that TNFR2 agonism can prevent and reverse OA-induced cardiac dysfunction in female mice and delay systolic decline in males, revealing sex-specific cardiac effects of OA.

This study shows leptin alleviates obesity hypoventilation by activating serotonergic neurons in the medullary raphe that innervate hypoglossal motoneurons.

This study shows setmelanotide reduces opioid-induced respiratory depression in mice without reversing analgesia.

This study shows oxytocin improves survival and respiratory function in rats with opioid-induced respiratory depression caused by fentanyl or fentanyl-xylazine combinations, outperforming naloxone in some cases.

This study characterizes a novel mouse model of OA-induced heart failure, revealing sex-specific cardiac remodeling and molecular pathways associated with different HF phenotypes.

This study investigates sex-specific cardiorenal dysfunction in EAE, finding distinct ER stress/UPR alterations and sex-dependent therapeutic responses to ERO1 inhibition and IRE1 activation.

This study identifies OXT receptor expression in brainstem cardiac vagal neurons and shows that OXT selectively activates DMNX CVNs to induce bradycardia.