Intravital single-cell behavior profiling reveals disrupted germinal center B cell motility and interactions by EZH2 gain-of-function mutation
Chanhong Min, Kibaek Choe, Xi Chen, Ioannis Karagiannidis, Nikita Sivakumar, Chris Xu, Ari Melnick, Jude M. Phillip, Wendy Béguelin
This study uses intravital imaging and single-cell analysis to show that EZH2 mutations alter GC B cell motility and interactions, promoting lymphomagenesis.
bioRxiv · Sep 7, 2026 · PreprintImmunology