Jude M. Phillip

Reprogramming CAR-T cell function through synthetic cytokine receptors suppresses metastatic progression of TNBC

This study enhances CAR-T cell migration through synthetic cytokine receptors, reducing metastasis in TNBC mouse models.

Intravital single-cell behavior profiling reveals disrupted germinal center B cell motility and interactions by EZH2 gain-of-function mutation

This study uses intravital imaging and single-cell analysis to show that EZH2 mutations alter GC B cell motility and interactions, promoting lymphomagenesis.

Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids

This study identifies distinct senescent cell populations in human fibroids and shows their role in ECM remodeling and vascular dysfunction through single-cell RNA sequencing and functional analysis.

Behavioral and Functional Profiling of Acomys cahirinus Fibroblasts Reveals Enhanced Matrix Remodeling Capacity

This study profiles Acomys cahirinus fibroblasts to show that Col3A1 expression and senescence-associated cell states influence matrix remodeling, contributing to scarless regeneration.

Neutrophil migration in the lung is altered by alveolar collapse and stretch

This study shows that alveolar collapse increases neutrophil migration speed, which is modulated by mechanical and biochemical factors.

Cell-nanoplastics association impacts cell proliferationand motility

This study quantitatively investigates how different nanoplastics associate with and affect diverse cell types, revealing cell-type-dependent impacts on proliferation and motility.

Monocytes are biological sensors of aging and frailty in humans

This study shows that monocyte behaviors can predict aging and frailty in humans using single-cell analysis and a deep learning model.

Acute priming using elevated fluid viscosity recovers young-like single-cellsurveillance behaviors in aged human T cells

This study shows that increasing fluid viscosity can temporarily restore young-like surveillance behaviors in aged human T cells by improving deformability and sensing.

Self-organizing ovarian somatic organoids preserve cellular heterogeneity and reveal cellular contributions to ovarian aging

This study develops ovarian somatic organoids that maintain cellular diversity and reveal age-related changes in cellular composition and function.

NLTD 2.0: A Nonlinear Framework for Robust and Customizable Color Deconvolution in Histopathology

NLTD 2.0 improves color deconvolution in histopathology by handling more than three stains without requiring optimal color vectors, enhancing reliability and accessibility through an ImageJ plugin.

Data-driven simulations elucidate how lymphocyte motility behaviors influence cell-cell interactions within germinal centers

The paper develops a computational framework to quantify lymphocyte motility behaviors and predict their impact on B-T interactions in germinal centers, finding that differential motility enhances B-T interaction rates.

Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

The paper introduces a framework for mathematical modeling of multicellular systems using interpretable cell behavior rules derived from biological knowledge and multi-omics data.

Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts

This study identifies functional senescence subtypes in aging human dermal fibroblasts using single-cell morphology and machine learning, showing subtype-specific responses to senotherapies.

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.

qMAP Enabled Microanatomical Mapping of Human Skin Aging

This study introduces qMAP, a deep learning-based workflow for microanatomical mapping of human skin, identifying 10 core processes strongly associated with aging and achieving age prediction accuracy comparable to epigenetic clocks.

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

This study shows that substrate stiffness affects the development and strength of senescence features in fibroblasts, with mechanosensitive regulation of key biomarkers.

Geometric changes in the nucleoids of Deinococcus radiodurans reveal involvement of new proteins in recovery from ionizing radiation.

This paper quantifies geometric changes in D. radiodurans nucleoids under ionizing radiation using a new high-throughput method, revealing sub-population shifts and roles of nucleic acid binding proteins in nucleoid condensation.

Particulate matter composition drives differential molecular and morphological responses in lung epithelial cells

The paper shows that different particulate matter mixtures cause distinct molecular and morphological changes in lung epithelial cells, with heavy metals causing more severe effects.

Use of the p-value as a size-dependent function to address practical differences when analyzing large datasets

The paper proposes a method to adjust p-values based on sample size to better detect differences in large datasets and reduce uncertainty in statistical decisions.