Chanhong Min

Reprogramming CAR-T cell function through synthetic cytokine receptors suppresses metastatic progression of TNBC

This study enhances CAR-T cell migration through synthetic cytokine receptors, reducing metastasis in TNBC mouse models.

Intravital single-cell behavior profiling reveals disrupted germinal center B cell motility and interactions by EZH2 gain-of-function mutation

This study uses intravital imaging and single-cell analysis to show that EZH2 mutations alter GC B cell motility and interactions, promoting lymphomagenesis.

Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroids

This study identifies distinct senescent cell populations in human fibroids and shows their role in ECM remodeling and vascular dysfunction through single-cell RNA sequencing and functional analysis.

Neutrophil migration in the lung is altered by alveolar collapse and stretch

This study shows that alveolar collapse increases neutrophil migration speed, which is modulated by mechanical and biochemical factors.

Monocytes are biological sensors of aging and frailty in humans

This study shows that monocyte behaviors can predict aging and frailty in humans using single-cell analysis and a deep learning model.

Acute priming using elevated fluid viscosity recovers young-like single-cellsurveillance behaviors in aged human T cells

This study shows that increasing fluid viscosity can temporarily restore young-like surveillance behaviors in aged human T cells by improving deformability and sensing.

Data-driven simulations elucidate how lymphocyte motility behaviors influence cell-cell interactions within germinal centers

The paper develops a computational framework to quantify lymphocyte motility behaviors and predict their impact on B-T interactions in germinal centers, finding that differential motility enhances B-T interaction rates.

AI-driven Classification of Cancer-Associated Fibroblasts Using Morphodynamic and Motile Features

This paper introduces an AI framework to classify cancer-associated fibroblasts using morphodynamic and motile features from live-cell imaging, complementing biomolecular approaches.

Single-cell morphology encodes functional subtypes of senescence in aging human dermal fibroblasts

This study identifies functional senescence subtypes in aging human dermal fibroblasts using single-cell morphology and machine learning, showing subtype-specific responses to senotherapies.