Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats
Ariadni Bella, Khaled Abdallah, Daniela Rodrígues-Amorím, Alba M Diego, Charles Decraene, Pierre Hener, Chiara Di Marino, David P. Finn, İpek Yalçın, Michelle Roche
This study shows that repeated restraint stress worsens post-surgical pain and anxiety in rats through β-adrenergic receptor activation and spinal NLRP3-IL1β signaling.
Neuropsychopharmacology · Jan 9, 2026Peer-reviewedNeuroscience