Charles Decraene

Repeated restraint stress-induced increase in post-surgical somatosensory hypersensitivity and affective responding is mediated by β-adrenergic receptor activation and spinal NLRP3-IL1β signalling in male rats

This study shows that repeated restraint stress worsens post-surgical pain and anxiety in rats through β-adrenergic receptor activation and spinal NLRP3-IL1β signaling.

Sex-divergent brain epigenetic reprogramming by chronic opioids

This study identifies sex-specific epigenetic changes in the nucleus accumbens of male and female mice exposed to chronic morphine, revealing shared biological dysregulation and potential therapeutic targets.

Designing new natural-mimetic phosphatidic acid: aversatile and innovative synthetic strategy forglycerophospholipid research

This paper introduces a new synthetic strategy for phosphatidic acid analogues that preserves acyl chain structure and enables flexible molecular grafting for biological studies.

Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies

This study reviews functional genomic mechanisms of opioid action and OUD across animal models and human studies, finding low consistency in gene expression results.