The tumor-maintaining function of UTX/KDM6A in DNA replication and the PARP1-dependent repair pathway
Lin-Wen Yeh, Je-Wei Chen, Jia-Yun Yeh, Mei-Han Kao, Hsiao-Chin Hong, Sean Wu, Wai‐Mui Cheung, Ta-Yu Liu, Marvin Angelo Esteban Aberin, Ernesto Paas-Oliveros, Arian Escajeda, Edward S.C. Shih, Woan‐Yuh Tarn, Yao‐Ming Chang, Lan-Hsin Wang, Shu‐Ping Wang
This paper identifies UTX/KDM6A's role in tumor maintenance through DNA replication and repair pathways, showing that targeting the protein, not just its enzymatic activity, could be a therapeutic strategy.
bioRxiv · May 31, 2024 · PreprintCancer Biology