Yao‐Ming Chang

BioTrajX: evaluating biological plausibility in single-cell trajectory inference

BioTrajX evaluates biological plausibility of single-cell trajectories using three metrics to compare different trajectory inference results.

Scube2 Modulates Coronary Vessel Formation during Cardiac Growth and Regeneration in Zebrafish

This study identifies Scube2 as a regulator of coronary vessel formation and heart regeneration in zebrafish, showing its role in vascular coverage, myocardial structure, and revascularization after injury.

The tumor-maintaining function of UTX/KDM6A in DNA replication and the PARP1-dependent repair pathway

This paper identifies UTX/KDM6A's role in tumor maintenance through DNA replication and repair pathways, showing that targeting the protein, not just its enzymatic activity, could be a therapeutic strategy.

Chromatin state transition underlies the temporal changes in gene expression during cardiomyocyte maturation

This study identifies RNF20-mediated chromatin state transitions as critical for time-ordered gene expression during cardiomyocyte maturation and links its disruption to congenital heart disease.

Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

The paper identifies distinct cardiac resident macrophage subpopulations critical for zebrafish heart regeneration through comparative single-cell profiling.

lncRNA HOTAIRM1 Coordinates with RNA Processing Factors in DNA Damage Repair

This study identifies HOTAIRM1 as a scaffold that coordinates RNA processing factors with DNA repair mechanisms to enhance double-strand break repair efficiency.