BioReason-Pro: Advancing Protein Function Prediction with Multimodal Biological Reasoning
Adibvafa Fallahpour, Arman Seyed-Ahmadi, Parsa Idehpour, Omar Ibrahim, Bong Gun Choi, Purav Gupta, Jack Naimer, Kevin Zhu, Abhinav Adduri, Arnav Shah, Shihao Ma, Talu Güloglu, Nuo Liu, Haotian Cui, Arihant Jain, , Bo Wang
A reasoning LLM combining ESM3 embeddings with GO-GPT term predictions produces protein function annotations that experts rated tie-or-better than UniProt in 79% of cases (SFT model).
bioRxiv · Jul 19, 2026 · PreprintMolecular Biology✦ In-depth digest