Alexander A. Nevue

The paper introduces a framework for designing and assembling combinatorial DNA barcodes for probe-based genomics, demonstrating their use in decoding complex RNA expression in mouse brains.

A reasoning LLM combining ESM3 embeddings with GO-GPT term predictions produces protein function annotations that experts rated tie-or-better than UniProt in 79% of cases (SFT model).

This paper introduces PerturbSpace, a method combining CRISPR perturbations with spatially hashed single-cell multiomics to study gene function in tissue architecture.

The paper shows that GPR108 absence in birds explains lower AAV transduction efficacy and demonstrates that human GPR108 expression and capsid modifications enhance transduction in zebra finch cells.

The paper identifies a direct cortical projection from the primary motor cortex to the nucleus ambiguus in two bat species, suggesting they have the anatomical substrate for vocal learning.

This study shows that a learned motor behavior can recover after chronic disruption of inhibitory circuits, with neuronal activity permanently altered but song recovery possible without relying on learning circuits.

The paper identifies Kv3.1 as a key channel enabling ultranarrow spikes in songbird RAPNs, analogous to Betz cells in primates, supporting precise motor control.

This study identifies resurgent Na+ currents in zebra finch projection neurons that enable ultrafast spiking for fine motor control.