Nuo Liu

This study shows that extracellular cGAMP worsens neuroinflammation in aging and MS by activating STING in microglia, astrocytes, and inhibitory neurons, with ENPP1 acting as a protective brake.

A reasoning LLM combining ESM3 embeddings with GO-GPT term predictions produces protein function annotations that experts rated tie-or-better than UniProt in 79% of cases (SFT model).

The paper introduces a method to compress phenotypic screens using computational deconvolution, demonstrating increased efficiency and applicability to complex multicellular models.

The paper extends the DTL model to account for gene family entry outside the species tree and genomic rearrangements, introducing an efficient algorithm for maximum parsimony reconciliation and preliminary integration into a tool for reconstructing genomic island histories.