Quantitative Seq-LGS: Genome-Wide Identification of Genetic Drivers of Multiple Phenotypes in Malaria Parasites
Hussein Molu Abkallo, Axel Martinelli, Megumi Inoue, Abhinay Ramaprasad, Phonepadith Xangsayarath, Jesse Gitaka, Jianxia Tang, Kazuhide Yahata, Augustin Zoungrana, Hayato Mitaka, Arita Acharjee, Partha P. Datta, Paul Hunt, Richard Carter, Osamu Kaneko, , Richard Leighton Culleton
This paper introduces a method to identify genetic drivers of multiple phenotypes in malaria parasites by combining LGS, sequencing, and mathematical modeling, demonstrating its effectiveness in detecting novel alleles for growth rate and strain-specific immunity.
PLoS Pathogens · Jul 12, 2017Peer-reviewedGenomics