Richard Leighton Culleton

The paper introduces a PCR-based assay that accurately distinguishes between Plasmodium ovalecurtisi and Plasmodium ovalewallikeri, with high sensitivity and specificity for malaria diagnosis.

The paper sequences the genome of Plasmodium simium to study its evolutionary history and identify genetic adaptations enabling host-switching to humans.

The paper generates high-quality genomes and phenotypes for ten Plasmodium vinckei isolates, revealing genomic diversity, selection pressures, and potential for genetic manipulation.

The paper shows that malaria parasites' intraerythrocytic cycle duration is influenced by coordination with host circadian rhythms, with gene expression and pathways affected when this coordination is disrupted.

This paper introduces a method to identify genetic drivers of multiple phenotypes in malaria parasites by combining LGS, sequencing, and mathematical modeling, demonstrating its effectiveness in detecting novel alleles for growth rate and strain-specific immunity.

The paper identifies Plasmodium simium as the cause of malaria outbreaks in Rio de Janeiro, demonstrating zoonotic transmission from monkeys to humans.