Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani
Supratim Pradhan, Dhruba Dhar, Debolina Manna, Shubhangi Chakraborty, Arkapriya Bhattacharyya, Khushi Chauhan, Rimi Mukherjee, Abhik Sen, Krishna Pandey, Soumen Das, Budhaditya Mukherjee
This study shows that drug-resistant Leishmania donovani strains exploit host lipids through enhanced endocytosis and lipid droplet accumulation, reducing their responsiveness to Amphotericin-B.
bioRxiv · Oct 21, 2024Microbiology